Zerodol SP tablet is a combination medicine that relaxes muscles, joints, and postoperative pain. It efficiently reduces pain and inflammation in conditions such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. This medicine should be taken at the recommended dose and duration. It should be consumed with food or milk to avoid stomach upset. Consuming the medicine daily at the right times improves the effectiveness. It is crucial continue consuming it until the doctor says otherwise.
In this article, we will explore everything about Zerodol SP uses, composition, price, and side effects. This will also cover the key benefits that the medicine has on your health.
Zerodol SP at a Glance
Zerodol SP contains a mixture of aceclofenac, paracetamol, and serraiopeptidase that comes under the category of Non-steroidal anti-inflammatory drugs (NSAIDs) that reduce swelling, analgesic, and proteolytic enzyme, respectively
- The tablet is produced and promoted by IPCA Laboratories Limited
- The tablet is used to diagnose swelling, inflammation, and fever conditions related to infections, surgeries, trauma, and other visceral pains that are mild to moderate.
- Zerodol SP is not only used for inflammation and swelling, but it also accelerates the healing process.
Zerodol SP Composition and Description
Zerodol SP tablet contains a combination of aceclofenac, paracetamol, and serratiopeptidase, which is generally prescribed to diagnose inflammation, swelling, and pain associated with conditions. It can be used to treat various mild-to-moderate visceral pains, and the diagnostic process appears to be improving more quickly.
Zerodol SP Tablet Uses
Tab Zerodol SP is used for diagnosing different conditions like swelling, inflammation, and pain that occur due to fever, injury, surgery, and infections. It is also used to treat mild to moderate visceral pain. Although it shows faster action in the healing process. It is also consumed to diagnose oedematous conditions. You can also learn zerodol sp tablet uses in hindi.
Price of Zerodol SP in India
The maximum retail price of Zerodol is Rs 118.30 as of 2023. Zerodol SP tablet is produced by IPCA Laboratories Ltd and is available at almost every pharmacy. You can also find this in Ahmedabad’s FFR Intas.
Things to Consider When Taking Zerodol SP
- Adults may have one tablet twice a day
- Zerodol SP tablets should be taken two hours after a meal
- The tablet can be consumed with a glass of water to avoid crushing or chewing
- The maximum dose of the aceclofenac is recommended to be 200 mg every day in separated doses
- The maximum daily dose of paracetamol is 4g.
- Serratiopeptidase can be used as much as 60 milligrams per day or as recommended by the doctor
- Ignore drug administration when hyperreaction that may cause rash, anaphylaxis, and serum sickness.
- Consume it in regular intervals daily to get a better outcome
- Do not consume two doses at the same time, as it can cause negative effects
- If you miss a dose, take the next dose immediately when you remember.
- Follow the diagnosis chart as directed by the doctor
Zerodol SP Mechanism of Action
The mechanism of action of the single drugs that are included in Zerodol SP is as follows:
Aceclofenac
The mechanism of action of aceclofenac encompassess inhibiting cyclooxygenase enzymes that are responsible for turning arachidonic acid into prostaglandins. This, in turn, produces analgesic and anti-inflammatory effects.
Prostaglandins are chemical compounds that cause pain, inflammation, and even fever.
Paracematol
Paracetamol generally expresses analgesic and antipyretic effects:
Paracetamol inhibits prostaglandin synthesis through peripheral action by preventing the pain impulse. Peripheral action results from the inhibition of prostaglandins, which sensitize pain receptors.
Paracetamol produces an antipyretic effect by acting on the hypothalamic heat-regulation center. It causes vasodilation, improving blood flow through the skin and promoting sweating and heat loss.
Serratiopeptidase
Serratiopeptidase exhibits anti-inflammatory, analgesic, and anti-oedemic effects.
Anti-inflammatory: Serratiopeptidase hydrolyses inflammatory mediators such as bradykinin, histamine, and serotonin.
Analgesic– Serratiopeptidase reduces pain by preventing the bradykinin
Anti-oedemic effect: By liquefying the fluid, reducing its accumulation in tissues, and facilitating fluid removal, serratiopeptidase reduces oedema. Furthermore, serratiopeptidase activity degraded tissue in the wound area, accelerating the healing process.
Learn about Kialodenzydaisis for healing and wellbeing.
Indications of Zerodol SP
This medicine is used to diagnose:
- Swelling, inflammation, and pain related to muscles, joints, fevers, surgeries, infections, and injuries.
- Different mild-to-moderate visceral pains
- Wound healing
- Oedematic conditions
- Pain in osteo, gynaec, and dentistry
Dosage of Zerodol SP
Zerodol is a tablet that is coated with aceclofenac IP 100 mg, Paracetamol IP 325 mg, and Serratiopeptidase IP 15 mg.
For the adults:
One tablet of Zerodol twice daily is generally advised by the doctors
For the geriatric:
In elderly patients with normal renal and hepatic function, this medicine is beneficial; in adults, use with caution as recommended by doctors.
Note: There is no dosing data for paediatrics. Also, the dosing information is collected from credible, trusted sources. Hence, we cannot confirm its accuracy or be responsible for any updation.
Side Effects of Zerodol SP
Zerodol SP is usually safe and does not have any side effects. However, in certain cases, it can cause some side effects according to the composition.
Aceclofenac Common and Rare Side Effects
| Common side effects | Rare side effects |
| Dyspepsia
Abdominal pain Nausea Diarrhoea Dizziness Increased levels of hepatic enzymes |
Granulocytopenia
Thrombocytopenia Neutropenia Haemolytic anaemia Depression Vertigo Hepatitis Oedema |
Paracetamol Side Effects
Paracetamol side effects are rare, and the reports reveal that some rare side effects are seen, such as:
- Blood dyscrasias
- Thrombocytopenic purpura
- Methemoglobinemia
- Agranulocytosis
- Skin rash
- Anaphylactic reaction
Serratiopeptidase Side Effects
- Rash or redness
- Hypersensitivity
- Muscle and joint pain
- Anorexia
- Nausea
- Vomiting
- Abdominal discomfort
- Diarrhoea
- Cough
- Epistaxis
- Haemoptysis
Contraindications of Zerodol SP
Zerodol SP should not be used in:
- Common hypersensitivity to aceclofenac, paracetamol, serratiopeptidase, or any element of the formulation
- Active or past history of peptic ulcer, bleeding, or bleeding disorders
- Past record of gastrointestinal bleeding or perforation related to past NSAID therapy
- Serious heart, hepatic, and renal failure
- Patients diagnosed with congestive heart failure, peripheral arterial illness, ischaemic heart disease, and cerebrovascular disease
- During the final trimester of pregnancy
- Patients with asthma, urticaria, or acute rhinitis may experience symptoms caused by aspirin or other NSAIDs.
- Acute porphyria
Zerodol SP Use Effect in Specific Conditions
Pregnant women: There is no proven evidence on pregnant women regarding the Zerodol SP combination drugs. However, reports are there that state the use of NSAIDs in the last trimester of pregnancy reduces uterine contractions.
Nursing women: There is no strong evidence on the secretion of aceclofenac and serine peptidase in breast milk. However, a few studies have found a small amount of paracetamol in breast milk. The decision to recommend this medicine by a doctor relies on the patient’s condition.
Pediatric patients: Safety and efficacy should be better developed in paediatric patients. Hence, it is not recommended for paediatric patients.
Geriatric patients: Generally, Zerodol is recommended for healthy elderly patients and not for those with serious renal, hepatic, and GI disorders.
Renal impairment patients: Paracetamol is generally excreted via the renal route; therefore, it is generally avoided in patients with renal impairment.
Hepatic impairment patients: NSAIDs cause liver toxicity in hepatic patients, and hence, it is prevented in renal patients.
While driving and operating machinery: Zerodol has undesirable effects like dizziness, drowsiness, and vertigo, and hence it is not suggested in these cases.
Zerodol SP Drug Interactions
A drug interaction is a reaction between two or more medicines, food, or supplements that results in an unpredictable reaction. When Zerodol is given with different drugs, there could be many effects. Zerodol interactions are:
Aceclofenac
+Lithium: Aceclofenac, like other NSAIDs, may increase plasma lithium concentrations, which can affect the risk of adverse effects.
+Digoxin: By impacting the kidneys, NSAIDs may aggravate heart failure, increase the level of plasma cardiac glucosides, and reduce the glomerular filtration rate in people with cardiac glycosides.
+Diuretics: Like other NSAIDs, aceclofenac may stop diuretics from performing as suggested. Although interactions with other diuretics cannot be overlooked, bendrofluazide did not affect blood pressure regulation.
Paracetamol
+Cholestyramine: Cholestyramine reduces the pace at which paracetamol is absorbed. Hence, if high analgesia is required, cholestyramine should not be prescribed within an hour.
+Domperidone with metoclopramide: The absorption of paracetamol is improved by domperidone with metoclopramide.
+Warfarin: Extended and regular use of paracetamol may raise the anticoagulant impact of warfarin and other coumarins, with a high risk of bleeding. Hence, there will be little or no effect.
+Chloramphenicol: Mixing paracetamol and chloramphenicol may largely reduce the pace of the drug’s elimination. This increases the plasma concentration and the chances of negative side effects. Mixing paracetamol and chloramphenicol injection is recommended.
Serratiopeptidase
+Anticoagulant/Antiplatelet drugs: When consumed with aspirin, warfarin, or clopidogrel, bleeding risk or wound up could be increased.
+Natural substances: Serratiopeptidase may increase the risk of bleeding or bruising when blended with some natural substances or organic ingredients like fish oil, turmeric, and garlic.
FAQs
Is Zerodol SP tablet safe to use?
Yes, it is safe for many patients. The medicine combines aceclofenac, paracetamol, and serratiopeptidase and is useful in most situations.
Why use Zerodol?
This table is used to diagnose conditions such as swelling, inflammation, and pain caused by injuries, infections, fever, and surgery.
Can I take Zerodol in pregnancy?
No proven trials have been conducted on pregnant women. However, research reveals that taking NSAIDs decreases uterine contractions during the last trimester of pregnancy.
Can I use Zerodol SP for a toothache?
Yes, you can use Zerodol for toothaches.
Does Zerodol SP cause dizziness?
Zerodol may cause dizziness in some populations because of its negative effects.
Also Read:
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